Advanced Dental Admission Test (ADAT)

What is the primary role of lipoxins in the body?

1. They promote cell division

2. They enhance bone healing

3. They limit the duration and magnitude of inflammation

4. They increase the production of mucus

The correct answer is: They limit the duration and magnitude of inflammation

The primary role of lipoxins in the body is to limit the duration and magnitude of inflammation. These specialized lipid mediators are derived from arachidonic acid and play a crucial part in resolving inflammation after an immune response. Lipoxins work by promoting the apoptosis (programmed cell death) of inflammatory cells, enhancing the clearance of these cells from the site of inflammation, and also signaling to other cells in the immune system to reduce the inflammatory response. This resolution phase is an essential component of maintaining homeostasis within the body's immune system. By modulating and tapering down inflammatory processes, lipoxins help prevent excessive tissue damage and chronic inflammation, which can lead to various diseases, including autoimmune disorders and chronic inflammatory conditions. In contrast, the other listed roles do not align with the function of lipoxins. While they do not promote cell division or enhance bone healing directly, and they play no significant role in increasing mucus production, their primary function is clearly centered around the regulation and resolution of inflammation.