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Conjugated hyperbilirubinemia is an elevated level of conjugated bilirubin in the blood, often associated with liver function and biliary obstruction. In the context of pregnancy, the third trimester is a critical period for the development of certain complications that can lead to conjugated hyperbilirubinemia.

During the third trimester, hormonal changes and the physical stresses of pregnancy can affect liver function and metabolism. Conditions such as cholestasis of pregnancy, which is characterized by bile flow obstruction and can lead to elevated levels of conjugated bilirubin, are more commonly observed in this stage. Additionally, the increased demand on the mother's liver due to the growing fetus and changes in bile composition can contribute to the risk of developing this condition.

Understanding the timing of these physiological changes is crucial for recognizing the potential for conjugated hyperbilirubinemia, making the third trimester a particularly relevant period in this context. The first and second trimesters typically do not showcase the same risk factors or physiological changes that would lead to this condition, while saying "any trimester" does not accurately highlight the specific increased risk associated with the third trimester.