Advanced Dental Admission Test (ADAT) 2026 – The Complete All-in-One Study Guide for Exam Success!

In Cushing's syndrome, there is an increase in cortisol levels due to various factors such as tumors in the pituitary gland or adrenal glands. This excess cortisol leads to alterations in the body’s response to certain hormones and neurotransmitters, including the beta-adrenergic receptors.

When cortisol levels are elevated, the body may exhibit a state of hyperreactivity to beta-adrenergic stimulation, which is often referred to as beta-adrenergic supersensitivity. This means that the body's beta receptors become more responsive to stimulation, resulting in heightened physiological responses such as increased heart rate and enhanced catecholamine effects. This mechanism is associated with the various cardiovascular and metabolic complications seen in patients with Cushing's syndrome.

The other options do not accurately reflect the physiological changes that occur in Cushing's syndrome. Beta-adrenergic sensitivity is not typically neutral or unaffected; rather, it shifts towards a heightened response due to the hormonal imbalances present in the condition.